Intrinsic Motions of DNA Polymerases Underlie Their Remarkable Specificity and Selectivity and Suggest a Hybrid Substrate Binding Mechanism
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چکیده
DNA replication is a fundamental biological process involving numerous enzymes that help to ensure the maintenance of genomic integrity. DNA polymerase enzymes are key components of this cellular replication machinery. Their primary function is to selectively incorporate correct nucleotide [i.e., a dNTP (where N1⁄4A, T, C or G), 20-deoxyribonucleoside 50-triphosphate] to pair with the template base in accordance with Watson-Crick DNA base pairing rules (i.e., A opposite T or G opposite C). The ability of polymerases to 1
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